Pathology
Neuroblastomas can arise anywhere throughout the sympathetic nervous system.
The adrenal gland is the most common primary site (40 percent), followed by abdominal (25 percent), thoracic (15 percent), cervical (5 percent), and pelvic sympathetic ganglia (5 percent) [4].
Less commonly, tumors arise within the central or autonomic nervous systems [1].
Neuroblastoma metastasizes to lymph nodes, bone marrow, cortical bone, dura, orbits, liver, and skin, and less frequently to pulmonary and intracranial sites (image 2 and image 3) [5].